Allergology

d202 - rDer p 1 (Dermatophagoides pteronyssinus)

Test details

This test is useful when a dust mite allergy is suspected and to identify the specific molecule that has previously caused a positive result in the associated allergen extract test.

 

Der p 1 is a cysteine protease located in the gut and in faecal particles of house dust mites. The prevalence of this molecule exceeds 70% among patients sensitised to Dermatophagoides pteronyssinus. Exposure to Der p 1 occurs through inhalation of mite faeces. Symptoms associated with an allergy to this molecule include, primarily, allergic rhinitis, conjunctivitis and coughing due to an itchy throat. In some cases, the allergy may cause skin symptoms and lead to bronchial asthma. There is a high degree of cross-reactivity with the Dermatophagoides farinae Der f 1 molecule. The assessment of sensitisations to Der p 1 is considered important for selecting patients eligible for allergen-specific immunotherapy (AIT).

Sample type

Serum

Method

ChLIA

Preparation

Fasting for at least 8-12 hours before sampling

Storage conditions

Refer to the Health Service Charter to check storage conditions

Shipping

+2/+8°C

References

Hamilton RG. Allergic sensitization is a key risk factor for but not synonymous with allergic disease. J Allergy Clin Immunol. 2014 Aug;134(2):360-1. doi: 10.1016/j.jaci.2014.02.022. Epub 2014 Mar 31. PMID: 24698318.

Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, et al. EAACI Molecular Allergology User's Guide. Pediatr Allergy Immunol. 2016 May;27 Suppl 23:1-250. doi: 10.1111/pai.12563. PMID: 27288833.

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