This test is useful when an allergy to crustaceans and molluscs is suspected and to identify the specific molecule that has previously caused a positive result in the associated allergen extract test.
rPen a 1 is a tropomyosin, muscle protein found in shrimp. It is considered a pan-allergen as it is also found in other invertebrates such as crustaceans (shrimp, lobsters, crabs, prawns), arachnids (house dust mites), insects (cockroaches) and molluscs (e.g., squid).
The prevalence of this molecule can exceed 80% in patients sensitised to shrimp and has a potential for determining sensitisation and cross-reactivity with tropomyosins from other species.
Due to its resistance to both heat and enzymatic digestion, individuals with a suspected allergy to Pen a 1 may experience gastrointestinal, skin and respiratory reactions, and even anaphylaxis, including after eating cooked shrimp.
Cross-reactivity may be detected especially with the Der p 10 molecule from house dust mites.
Serum
ChLIA
Fasting for at least 8-12 hours before sampling
Refer to the Health Service Charter to check storage conditions
+2/+8°C
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Test for the determination of human autoantibodies against NMDAR to support the diagnosis of paraneoplastic neurological syndromes with an intermediate-risk phenotype.
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