f423 - rAra h 2 (Peanuts)
Test details
This test is useful when a peanut allergy is suspected and to identify the specific molecule that has previously caused a positive result in the associated allergen extract test.
Ara h 2 is a seed storage protein called conglutin and is part of the 2S albumin family. Individuals sensitised to Ara h 2 have a higher risk of severe symptoms and anaphylactic reactions, as Ara h 2 is one of the most potent and frequently recognized peanut allergens. Roasting peanuts at high temperatures increases the allergenicity of Ara h 2.
Due to its resistance to both heat and enzymatic digestion, individuals with a suspected allergy to Ara h 2 may experience gastrointestinal, skin and respiratory reactions, and even anaphylaxis.
Cross-reactivity may occur especially with almond and Brazil nut allergens.
Sample type
Serum
Method
ChLIA
Preparation
Fasting for at least 8-12 hours before sampling
Storage conditions
Refer to the Health Service Charter to check storage conditions
Shipping
+2/+8°C
References
Hamilton RG. Allergic sensitization is a key risk factor for but not synonymous with allergic disease. J Allergy Clin Immunol. 2014 Aug;134(2):360-1. doi: 10.1016/j.jaci.2014.02.022. Epub 2014 Mar 31. PMID: 24698318.
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, et al. EAACI Molecular Allergology User's Guide. Pediatr Allergy Immunol. 2016 May;27 Suppl 23:1-250. doi: 10.1111/pai.12563. PMID: 27288833.
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