This test is useful when an apple allergy or PR-10 cross-reactivity are suspected, and to identify the specific molecule that has previously caused a positive result in the associated allergen extract test.
Mal d 1 is a protein found mainly in the skin but also in the flesh of the apple, and belongs to the PR-10 group (Bet v 1 type).
Since the protein is sensitive to heat and proteolysis, peeling the apple or consuming it cooked rather than raw may be an effective way to limit exposure to Mal d 1.
A strong cross-reactivity with the Bet v 1 molecule from birch pollen has been observed.
Within a few minutes of eating an apple, individuals sensitised to Mal d 1 develop symptoms related to oral allergy syndromes (OAS), including itching of the mouth, redness of the oral mucosa or angioedema of the lips, tongue, or throat.
Cross-reactivity may also occur with pears, peaches, and cherries.
Serum
ChLIA
Fasting for at least 8-12 hours before sampling
Refer to the Health Service Charter to check storage conditions
+2/+8°C
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