Allergology

g213 - rPhl p 1, rPhl p 5b (Phleum pratense)

Test details

This test is useful when a grass pollen allergy is suspected and to identify the specific molecules that has previously caused a positive result in the associated allergen extract test.
Phl p 1 and Phl p 5b are proteins found in grass pollen and classified as group 1 and group 5 allergens, respectively.
Allergens in these grass pollen groups are glycosylated proteins that act as cross-reactive antigens in most grass and maize species.
The prevalence of both Phl p 1 and Phl p 5b is up to 90% among patients sensitised to grass pollen.
Symptoms associated with an allergy to this molecule mainly include allergic rhinitis, conjunctivitis, and coughing caused an itchy throat; in some cases, the allergy may also cause skin symptoms and lead to bronchial asthma.
The assessment of sensitisation to Phl p 1 and Phl p 5b is considered important for selecting patients eligible for allergen-specific immunotherapy (AIT).

Sample type

Serum

Method

ChLIA

Preparation

Fasting for at least 8-12 hours before sampling

Storage conditions

Refer to the Health Service Charter to check storage conditions

Shipping

+2/+8°C

References

Hamilton RG. Allergic sensitization is a key risk factor for but not synonymous with allergic disease. J Allergy Clin Immunol. 2014 Aug;134(2):360-1. doi: 10.1016/j.jaci.2014.02.022. Epub 2014 Mar 31. PMID: 24698318.

Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, et al. EAACI Molecular Allergology User's Guide. Pediatr Allergy Immunol. 2016 May;27 Suppl 23:1-250. doi: 10.1111/pai.12563. PMID: 27288833.

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