Neurology

Anti-Cardiac and Skeletal Muscle Antibodies

Test details

Myasthenia gravis is an autoimmune disease mediated by pathogenic autoantibodies targeting specific antigens of the postsynaptic membrane (AChR and MuSK), or muscle antigens (titin, ryanodine receptor).
The diagnostic significance of autoantibodies directed against striated muscle is relevant when antibody titers are high, while low titers may indicate reduced disease activity.


Autoantibodies against striated muscle can also be present in patients with other myopathies and in those with Chagas disease.

Sample type

Serum, EDTA plasma, heparin plasma, citrate plasma

Method

IFA tissue

Preparation

Fasting for at least 8-12 hours before sampling

Storage conditions

Refer to the Health Service Charter to check storage conditions

Shipping

+2/+8°C

References

Suzuki S, Utsugisawa K, Nagane Y, Suzuki N. Three types of striational antibodies in myasthenia gravis. Autoimmune Dis. 2011;2011:740583. doi: 10.4061/2011/740583. Epub 2011 Jul 17. PMID: 21785709; PMCID: PMC3139883.

Meriggioli MN, Sanders DB. Muscle autoantibodies in myasthenia gravis: beyond diagnosis? Expert Rev Clin Immunol. 2012 Jul;8(5):427-38. doi: 10.1586/eci.12.34. PMID: 22882218; PMCID: PMC3505488.

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