Anti-Cardiac and Skeletal Muscle Antibodies
Test details
Myasthenia gravis is an autoimmune disease mediated by pathogenic autoantibodies targeting specific antigens of the postsynaptic membrane (AChR and MuSK), or muscle antigens (titin, ryanodine receptor).
The diagnostic significance of autoantibodies directed against striated muscle is relevant when antibody titers are high, while low titers may indicate reduced disease activity.
Autoantibodies against striated muscle can also be present in patients with other myopathies and in those with Chagas disease.
Sample type
Serum, EDTA plasma, heparin plasma, citrate plasma
Method
IFA tissue
Preparation
Fasting for at least 8-12 hours before sampling
Storage conditions
Refer to the Health Service Charter to check storage conditions
Shipping
+2/+8°C
References
Suzuki S, Utsugisawa K, Nagane Y, Suzuki N. Three types of striational antibodies in myasthenia gravis. Autoimmune Dis. 2011;2011:740583. doi: 10.4061/2011/740583. Epub 2011 Jul 17. PMID: 21785709; PMCID: PMC3139883.
Meriggioli MN, Sanders DB. Muscle autoantibodies in myasthenia gravis: beyond diagnosis? Expert Rev Clin Immunol. 2012 Jul;8(5):427-38. doi: 10.1586/eci.12.34. PMID: 22882218; PMCID: PMC3505488.
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