Anti–ITPR1 Antibodies

Neurology

Recommended for patients with suspected autoimmune movement disorders or paraneoplastic neurological syndromes. In particular, patients positive for anti-ITPR1 antibodies may present with cerebellar ataxia.

Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1; also called Sj) is located in the cytoplasm and dendrites of Purkinje cells and plays a key role in regulating intracellular calcium homeostasis.

Serum, EDTA plasma, heparin plasma, citrate plasma, CSF

Immunoblot, IFA cells

Fasting for at least 8-12 hours before sampling

Refer to the Health Service Charter to check storage conditions

+2/+8°C

References

Jarius S, Wildemann B. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. J Neuroinflammation. 2015 Sep 17;12:166. doi: 10.1186/s12974-015-0356-y. PMID: 26377085; PMCID: PMC4574226.

Jarius S, Bräuninger S, Chung HY, Geis C, Haas J, Komorowski L, Wildemann B, Roth C. Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature. J Neuroinflammation. 2022 Jul 30;19(1):196. doi: 10.1186/s12974-022-02545-4. PMID: 35907972; PMCID: PMC9338677.

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Anti–NMDAR Antibodies

Test for the determination of human autoantibodies against NMDAR to support the diagnosis of paraneoplastic neurological syndromes with an intermediate-risk phenotype.

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Test details

Sample type

Method

Preparation

Storage conditions

Shipping

References

laboratory analysis

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Total tau

Phosphorylated Tau (pTau181)

Anti–NMDAR Antibodies

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