w230 - nAmb a 1 (Ambrosia elatior)
Test details
This test is useful when a ragweed pollen allergy is suspected and to identify the specific molecule that has previously caused a positive result in the associated allergen extract test.
Amb a 1 is a pectate lyase protein found in ragweed pollen.
The average prevalence of this molecule can exceed 90% in patients sensitised to ragweed pollen.
Cross-reactivity is possible with other pollens such as mugwort and sunflower.
Symptoms associated with an allergy to this molecule mainly include allergic rhinitis, conjunctivitis, and coughing caused an itchy throat; in some cases, the allergy may also cause skin symptoms and lead to bronchial asthma.
The assessment of sensitisations to Amb a 1 is considered important for selecting patients eligible for allergen-specific immunotherapy (AIT).
Sample type
Serum
Method
ChLIA
Preparation
Fasting for at least 8-12 hours before sampling
Storage conditions
Refer to the Health Service Charter to check storage conditions
Shipping
+2/+8°C
References
Hamilton RG. Allergic sensitization is a key risk factor for but not synonymous with allergic disease. J Allergy Clin Immunol. 2014 Aug;134(2):360-1. doi: 10.1016/j.jaci.2014.02.022. Epub 2014 Mar 31. PMID: 24698318.
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, et al. EAACI Molecular Allergology User's Guide. Pediatr Allergy Immunol. 2016 May;27 Suppl 23:1-250. doi: 10.1111/pai.12563. PMID: 27288833.
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